Fatty Acids in Heterocyclic Synthesis. Part XVII: Synthesis of Non Ionic Surfactants Containing Piperidine, Piperazine, Imidazole Based on Thiadiazole and Microbiological Activities Evaluation

• 作者: Abdelmotaal Abdelmajeid Mahasen Saad Amine Reda Ali Hassan
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: 2-Aminothiadiazole IMIDAZOLE THIAZOLE Stearic Acid THIAZOLIDINE Propylene Oxide NONIONIC Surfactant Antimicrobial Activity
• 年，卷（期）: 2017,（4）
• 页码范围: 346-368
• 页数: 23页
• 分类号: O6

摘要

A series of novel scaffolds Thiadiazolyl Piperidine, Thiadiazolyl Piperazine, thiadiazolidine, Thiadiazolyl thiazole and Thiadiazolyl-imidazole-Thione were synthesized from cheap, available and biologically active stearic acid. 2-amino-5-heptadecyl 1,3,4-thiadiazole reacts with chloroacetyl chloride and produced 2-choloro-N-(5-heptadecyl-1,3,4-Thiadiazole-2-yl) acetamide. Which allowed to react with Piperidine, Piperazine, urea and/or Thiourea and Potassium thiocyanate, and the latest scaffolds have been synthesized, respectively, and the structures of these compounds were established by elemental analysis, MS, IR and 1H-NMR spectral data. The antimicrobial activities of the synthesized compounds were evaluated in-vitro against strains of gram +ve, gram -ve bacteria and fungi. Nonionic surfactant were obtained by addition of different moles of propylene oxide (3,5,7 mole) to the synthesized compounds bearing an active hydrogen. Physico-chemical and surface properties as well as biodegradability of the synthesized non-ionic surfactants were evaluated.