Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of <i>Syzygium aromaticum</i>in Albino Rats

• 作者: Ahmed E. Amin Osman A. Osman Samia M. A. El Badwi Twadu A. Saeed
• 来源期刊: 生命科学与技术进展(英文)
• 学科: 医学
• 关键词: SYZYGIUM aromaticum Ethanolic EXTRACT Safety ANTI-INFLAMMATORY RATS
• 年，卷（期）: smkxyjsjzyw_2017,（11）
• 页码范围: 411-420
• 页数: 10页
• 分类号: R28

摘要

The present study was undertaken to investigate the effect of the ethanolic extract of Syzygium aromaticum to albino rats. Forty eight Albino rats were employed to test the safety and the anti-inflammatory effect of the extract. Safety of the extract was examined on experimental animal’s model at three dose levels of the extract orally in daily doses for three weeks. Effects of S. aromaticum on rats revealed no significant effect on biochemical or haematological parameters. The anti-inflammatory effect of the extract was tested in four equal groups;groups 1 and 2 were treated with 250 and 500 mg/kg of the extract, respectively, group 3 was treated with indomethacine and group 4 was the untreated control. Carrageenan was used as an acute form inducer of inflammation. Indomethacine, the non-steroidal anti-inflammatory drugs (NSAIDs), was used as a reference compound. Oedema size was monitored at the 1st, 2nd, 4th, 6th and after 24 hours. The ethanolic extract of S. aromaticum showed significant (P 0.001) decreased in the oedema size at efficacy rates of 79.41%, 82.39% and 63.92% for the dose, 500 mg/kg body weight at the 2nd, 4th and 6th hour respectively higher than that produced by indomethacine.