Antidiabetic and Antioxidant Effects of Methanolic Extracts of Leaf and Seed of <i>Tetracarpidium conophorum</i>on Alloxan-Induced Diabetic Wistar Rats

• 作者: Nankang G. Lepzem Rachel Adetoro Togun
• 来源期刊: 生物医学工程(英文)
• 学科: 医学
• 关键词: ANTIDIABETIC Glucose MDA GSH LIPIDS T. conophorum
• 年，卷（期）: swyxgcyw_2017,（8）
• 页码范围: 402-420
• 页数: 19页
• 分类号: R28

摘要

Methanolic extracts of Tetracarpidium conophorum (TCME) leaf, seed or leaf + seed extract demonstrated high capacity for reversing hyperglycemia and oxidative stress comparable with the standard anti-diabetic drug, metformin, in alloxan-induced diabetic rats. The leaf + seed extracts showed the best activity among the extracts and also ameliorated oxidative stress-induced damage of pancreas and liver tissue to normal state.