Development of an Artificial Finger-Like Knee Loading Device to Promote Bone Health

• 作者: Hiroki Yokota Sandeep Korupolu Sohel Anwar Stanley Chien
• 来源期刊: 生物医学工程(英文)
• 学科: 医学
• 关键词: OSTEOBLASTS Mechanical Loading Artificial HAND BONE Growth
• 年，卷（期）: swyxgcyw_2017,（11）
• 页码范围: 550-561
• 页数: 12页
• 分类号: R73

摘要

This study presents the development of an innovative artificial finger-like device that provides position specific mechanical loads at the end of the long bone and induces mechanotransduction in bone. Bone cells such as osteoblasts are the mechanosensitive cells that regulate bone remodelling. When they receive gentle, periodic mechanical loads, new bone formation is promoted. The proposed device is an under-actuated multi-fingered artificial hand with 4 fingers, each having two phalanges. These fingers are connected by mechanical linkages and operated by a worm gearing mechanism. With the help of 3D printing technology, a prototype device was built mostly using plastic materials. The experimental validation results show that the device is capable of generating necessary forces at the desired frequencies, which are suitable for the stimulation of bone cells and the promotion of bone formation. It is recommended that the device be tested in a clinical study for confirming its safety and efficacy with patients.