Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)

• 作者: Boris A. Katsnelson Ekaterina V. Shishkina Ilya V. Zubarev Ilzira A. Minigalieva Irene E. Valamina Larisa I. Privalova Marina P. Sutunkova Oleg H. Makeyev Svetlana V. Klinova Vladimir B. Gurvich Vladimir Ya. Shur
• 来源期刊: 环境保护(英文)
• 学科: 医学
• 关键词: NANOPARTICLES TOXIC metals Bioptotectors
• 年，卷（期）: 2017,（8）
• 页码范围: 844-866
• 页数: 23页
• 分类号: R73

摘要

Especially high health risks associated with impacts of metallic nanoparticles (Me-NPs) and their presence in the workplace and ambient air of not only the nano-industry but also of some long-existing traditional technologies make it necessary, along with keeping respective dangerous exposures as low as possible, to look for ways of increasing the organism’s resistance to them. Based on theoretical premises of such beneficial interference with toxicokinetics and toxicodynamics of Me-NPs developed by our research team and on understanding general and specific key mechanisms of different Me-NPs’ toxic action, we proposed several bioprotective complexes (BPCs) comprising mainly pectin, some vitamins, glutamate, glycine, N-acetylcysteine, omega-3 PUFA, and different essential trace elements. Results of our animal experiments with different Me-NPs showed that, against the background of such BPCs’ oral administration, the integral and specific toxicity of Me-NPs and even their genotoxicity can be markedly attenuated. Therefore we would recommend to further develop this vector of nano-toxicological research.