Efficacy of Prucalopride in bowel cleansing before colonoscopy:Results of a pilot study

• 作者: Chiara Coluccio Emilio di Giulio Giulio Antonelli Lucia D’Alba Vito Domenico Corleto
• 来源期刊: 世界胃肠内镜杂志：英文版（电子版）
• 学科: 医学
• 关键词: 清洁的肠 COLONOSCOPY PRUCALOPRIDE 屏蔽 Colorectal 癌症
• 年，卷（期）: 2017,（11）
• 页码范围: 558-560
• 页数: 3页
• 分类号: R735.34

摘要

Colonoscopy is a crucial diagnostic instrument for colorectal cancer screening and an adequate bowel preparation is definitely decisive for the success of the procedure. Especially in elderly patients, bowel cleansing is considered a big issue, because it is often poorly tolerated for many reasons(like inability to swallow large volume of liquids or unlikable taste); this can cause a suboptimal preparation that may lead to miss a neoplastic lesion. There is relatively little data about how to improve preparation tolerability. The purpose of our pilot study was to analyze the effect of prucalopride(Resolor~?), a highly selective serotonin 5HT4 receptor agonist used for chronic constipation for its ability to stimulate gastrointestinal peristalsis, undertaken the day before colonoscopy, followed by half volume of polyethylene glycol solution. We found that this can be a good and safe method to achieve an adequate and better-tolerated colon cleansing.