Analysis on Correlation between Resistin—420C/G Polymorphism and Type 2 Diabetes Mellitus Macroangiopathy in Han Population of Northeast China

• 作者: Bingxue Qi Ma Yan Yadong Sun
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: Type 2 Diabetes MELLITUS RESISTIN Gene POLYMORPHISM MACROANGIOPATHY POLYMERASE Chain Reaction
• 年，卷（期）: 2017,（12）
• 页码范围: 17-23
• 页数: 7页
• 分类号: R5

摘要

Objective: To study the allelic and genotypic frequency distribution of RETN—420C/G single nucleotide polymorphisms (SNPs) and its relationship with type 2 diabetes mellitus (T2DM) complicated with macroangiopathy in Han population of northeast China. Methods: The genotypes and their frequencies of a total of 180 cases, including 60 cases of T2DM complicated with macroangiopathy, 60 cases of simple T2DM and 60 cases of normal control (ND), were measured by PCR—RFLP. Results: The allelic frequencies and simple CC/GC + GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group (P Conclusion: The RETN—420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.