异基因造血干细胞移植后EB病毒相关性淋巴组织增殖性疾病的临床分析

• 作者: 冯四洲 古再丽努尔.吾甫尔 杨栋林 韩明哲
• 来源期刊: 临床血液学杂志
• 学科: 医学
• 关键词: EB病毒 移植后淋巴组织增殖性疾病 造血干细胞移植 利妥昔单抗
• 年，卷（期）: 2017,（3）
• 所属期刊栏目: 病例报告
• 页码范围: 225-228
• 页数: 4页
• 分类号: R551.2
• 语种: 中文
• DOI: 10.13201/j.issn.1004-2806.2017.03.018

摘要

To improve the understanding of EB virus associated post-transplant lymphoproliferative disorder (EBV-PTLD) after allogeneic hematopoietic stem cell transplantation,and to explore the early diagnosis and treatment of EBV-PTLD.The clinical data of 2 cases of acute lymphoblastic leukemia patients who had EBV-PTLD after unrelated donor transplantation were reported.Both of them were pretreated with TBI+CTX+Flu+Ara-C+ATG (rabbit) before unrelated donor transplantation.EBV-DNA increment,fever and lymphadenectasis occurred on day 41th and day 67th after transplantation respectively.The two patients received the preemptive therapy of reduction of CsA and application of rituximab.All clinical symptoms were completely disappeared.Dynamic monitoring of EBV-DNA is important for patients with high risk factors of EBV-PTLD.The prognosis of EBV-PTLD can be improved by early application of rituximab and the reduction of immunosuppression.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	古再丽努尔.吾甫尔		1	0	0.0	0.0
2	杨栋林		1	0	0.0	0.0
3	冯四洲		1	0	0.0	0.0
4	韩明哲		1	0	0.0	0.0