嗜碱性粒细胞增多的急性白血病1例报告并文献复习

• 作者: 刘凯奇 周春林 张广吉 彭楠 王建祥 王迎 秘营昌 邱少伟 魏辉 魏述宁
• 来源期刊: 临床血液学杂志
• 学科: 医学
• 关键词: 白血病,急性 嗜碱性粒细胞增多
• 年，卷（期）: 2017,（7）
• 所属期刊栏目: 病例报告
• 页码范围: 548-550
• 页数: 3页
• 分类号: R733.71
• 语种: 中文
• DOI: 10.13201/j.issn.1004-2806.2017.07.017

摘要

To explore the differential diagnosis of acute leukemia with basophilia,we analyzed clinical features,morphology,immunophenotyping,cytogenetics and molecular genetics from one case and reviewed relevant literatures.The patient had fatigue,fever,cough and splenomegaly.Mature basophils increased in the peripheral blood,bone marrow samples and electron microscopic evaluation.Bone marrow aspiration showed 54 ％ mature basophils.The blasts fulfilled the criteria of acute myeloid leukemia.Immunophenotyping revealed CD34+,HLA-DR+,CD117+,CD33+,CD13+,CD123+,CD38+.Fluorescence in situ hybridization found loss of P53/CEP17 and positive for BCR/ABL.The BCR/ABL p230 transcript determined by RT-PCR was 99.56％.Acute leukemia with basophilia is not common.Chronic myelogenous leukemia in blast crisis,acute myeloid leukemia with t(9;22)(q34;q11) or other abnormalities and basophilic leukemia can have basophilia,hence the differential diagnosis is useful in making a clear diagnosis and choosing an appropriate treatment.