The association of lumican polymorphisms and high myopia in a Southern Chinese population

• 作者: Bing Qi Gui-Fang Wang Guo-Cheng Yu Jing-Xiang Zhong Lian Liu Qing-Shan Ji
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 年，卷（期）: 2017,（10）
• 页码范围: 1516-1520
• 页数: 5页
• 分类号: R77

摘要

AIM:To investigate the correlation between lumican(LUM) gene and high myopia in a Southern Chinese population.METHODS:The study comprised of 95 high myopia patients with a spherical equivalent ≤-6.5 diopters(D).The control group recruited 95 individuals with a spherical equivalent ranging from-0.5 D to +0.5 D.Direct sequencing was used to detect the single nucleotide polymorphisms(SNPs) of LUM gene in coding region.Genotype distributions were tested for Hardy-Weinberg disequilibrium.Genotypic and allelic frequencies were analyzed through Chi-square test or Fisher's exact test.RESULTS:We identified 3 SNPs of the LUM gene:LUM c.32(rs577456426),LUM c.507(rs17853500) and LUM c.849(rs181915277).Among the three SNPs,the genotype and allele frequencies of rs17853500 showed a significant difference between patients and control subjects(P<0.05).However,there were no significant differences in rs181915277 and rs577456426 between the two groups(P>0.05).CONCLUSION:LUM c.507 polymorphism may be a risk factor for the pathogenesis of high myopia in the Southern Chinese population.