非输血依赖型地中海贫血铁过载治疗进展

• 作者: 刘容容 赖永榕 韦小云
• 来源期刊: 临床血液学杂志
• 学科: 医学
• 关键词: 非输血依赖型地中海贫血 铁过载 治疗 祛铁药 铁调素
• 年，卷（期）: 2017,（7）
• 所属期刊栏目: 综述
• 页码范围: 557-560
• 页数: 4页
• 分类号: R556
• 语种: 中文
• DOI: 10.13201/j.issn.1004-2806.2017.07.020

摘要

The problem of iron overload in non-transfusion-dependent-thalassemia (NTDT) has gradually attracted people's attention.Invalid overproduction of red blood cells in vivo,which induces hepcidin expression decrease and prompts increased intestinal iron absorption,leads to iron overload.The second complications resulting from iron overload affect NTDT patient's quality of life and life expectancy.Iron chelator is the only effective therapy at present.The adverse events and other limits urge us to find novel ways to cure the iron over-load.Currently,in Hbbth3/+ mouse model,increasing hepcidin expression through different methods can achieve better therapeutic effect of chelation,however,the clinical safety and effect of this way is not yet clear.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	赖永榕		158	483	10.0	13.0
2	刘容容		18	51	5.0	6.0
3	韦小云		1	0	0.0	0.0