Potential role of Müller cells in the pathogenesis of macropsia associated with epiretinal membrane： a hypothesis revisited

• 作者: Ahmet Colakoglu Solmaz Balci Aka
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: macropsia metamorphopsia epiretinal 膜 M 蚺 ? 蟩 ? 髧肸? 螁 ?? ē
• 年，卷（期）: 2017,（11）
• 页码范围: 1759-1767
• 页数: 9页
• 分类号: R77

摘要

Pathophysiological explanations for metamorphopsia associated with retinal pathologies generally focus on photoreceptor organization disruption. However, the retinal microarchitecture is complicated, and we hypothesize that other retinal cells may also be involved. Metamorphopsia has been widely studied in eyes with epiretinal membranes and we revisit the idea that Müller cell displacement causes retinal macropsia. A Pub Med query and related article search for the macula ultrastructure under normal and pathological conditions revealed an enormous amount of information, particularly ultrahigh definition optical coherence tomography and other retinal imaging modality studies. Findings of these imaging studies support our hypothesis that Müller cells, and not cone photoreceptors, are primarily responsible for macropsia in eyes with epiretinal membranes. More specifically, we conclude that displacement of Müller cell endfeet, and not photoreceptor cones, is a more likely the explanation for retinal macropsia associated with epiretinal membranes.