Na+—葡萄糖协同转运体在肿瘤细胞能量代谢中的作用

• 作者: 单春光 张瑞敬 徐鸥 王亚波
• 来源期刊: 临床耳鼻咽喉头颈外科杂志
• 学科: 医学
• 关键词: Na+—葡萄糖协同转运体 肿瘤细胞的能量代谢 新的治疗靶点
• 年，卷（期）: 2017,（6）
• 所属期刊栏目: 综述
• 页码范围: 482-486
• 页数: 5页
• 分类号: R739.6
• 语种: 中文
• DOI: 10.13201/j.issn.1001-1781.2017.06.018

摘要

Glucose is a major metabolic substrate required for cancer cell survival and growth.Instead,the entry of glucose molecules into the cells is effected by a large family of structurally related transport proteins known as glucose transporters.Two main types of glucose transporters have been identified,namely,the passive facilitative glucose transporters(GLUTs) and the secondary active sodium-coupled glucose transporters(SGLTs).However,tumor cells may adapt to an ischemic microenvironment by upregulation of SGLTs in the plasma membrane which supplies the tumor cell with glucose even at very low extracellular glucose concentration.Therefore,SGLTs is essential for ischemic and hypoxic tumor cells to uptake glucose.Current research indicates that SGLTs may become a promising biomarker for cancer therapy.