Plasma cell granuloma is a kind of the disease with low incidence at head and neck,which is a benign lesions with malignant biological performance.The diagnosis of plasma cell granuloma is difficult as the symptom is not typical and it is difficult to distinguish with cancers and other diseases through the physical sign and imaging manifestation.The golden standard of diagnosis is histopathological examination.The therapy of plasma cell granuloma is still controversial,but the first choice is the operation.The other therapy such as hormone therapy,radiotherapy,chemotherapy etc.,should be applied according to special conditions.Surgery has advantage with high cure rate and very low reoccurance rate.In this paper,we reported a case of plasma cell granuloma,occurred in maxillary sinus and summarizes the experiences about diagnosis and therapy of plasma cell granuloma in maxillary sinus through review previous literature.