Retinoic acid receptor beta promoter methylation and risk of cervical cancer

• 作者: Chaninya Wongwarangkana Jira Chansaenroj Nasamon Wanlapakorn Yong Poovorawan
• 来源期刊: 世界病毒学杂志
• 学科: 医学
• 关键词: METHYLATION Cervical cancer RETINOIC acid receptor BETA Human PAPILLOMAVIRUS RISK correlation Promoter
• 年，卷（期）: 2018,（1）
• 页码范围: 1-9
• 页数: 9页
• 分类号: R

摘要

Cervical cancer is one of the leading causes of death in women worldwide,particularly in developing countries.Human papillomavirus has been reported as one of the key etiologic factors in cervical carcinoma.Likewise,epigenetic aberrations have ability to regulate cancer pathogenesis and progression.Recent research suggested that methylation has been detected already at precancerous stages,which methylation markers may have significant value in cervical cancer screening.The retinoic acid receptor beta(RARβ)gene,a potential tumor suppressor gene,is usually expressed in normal epithelial tissue.Methylation of CpG islands in the promoter region of the RARβgene has been found to be associated with the development of cervical cancer.To investigate whether RARβmethylation is a potential biomarker that predicts the progression of invasive cancer,we reviewed 14 previously published articles related to RARβmethylation.The majority of them demonstrated that the frequency of RARβpromoter methylation was significantly correlated with the severity of cervical epithelium abnormalities.However,methylation of a single gene may not represent the best approach for predicting disease prognosis.Analyzing combinations of aberrant methylation of multiple genes may increase the sensitivity,and thus this approach may serve as a better tool for predicting disease prognosis.