Vitamin C in the critically ill-indications and controversies

• 作者: Christoph S Nabzdyk Edward A Bittner
• 来源期刊: 世界重症医学杂志
• 学科: 医学
• 关键词: Ascorbic acid VITAMIN C SEPSIS Shock Critical care medicine VASOPRESSORS CARDIOVASCULAR
• 年，卷（期）: 2018,（5）
• 页码范围: 52-61
• 页数: 10页
• 分类号: R

摘要

Ascorbic acid(vitamin C)elicits pleiotropic effects in the body.Among its functions,it serves as a potent antioxidant,a co-factor in collagen and catecholamine synthesis,and a modulator of immune cell biology.Furthermore,an increasing body of evidence suggests that highdose vitamin C administration improves hemodynamics,end-organ function,and may improve survival in critically ill patients.This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential.