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摘要:
Muscle biopsies from two female patients with systemic sclerosis (SS) and an inflammatory myopathy were studied ultrastructurally in relation to the possible presence of apoptosis in skeletal muscle fibers. Undergoing apoptosis showed characteristic morphological features of this process, including chromatin aggregation as well as nuclear and sarcoplasmic partition into membrane bound-vacuoles (apoptotic bodies) which contained autophagosomes, mitochondria, isolated myofilaments and nuclear material. Vacuoles exhibited different diameters and were covered by single membranes, appearing beneath basement membrane. Apoptosis occurred in some fiber segments as in necrosis or included whole atrophied fibers. These results indicate that apoptosis coexists with necrosis in the inflammatory myopathy of SS.
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篇名 Ultrastructural Aspects of Apoptosis in Systemic Sclerosis Inflammatory Myopathy
来源期刊 显微镜研究(英文) 学科 医学
关键词 APOPTOSIS SKELETAL Muscle Fiber SYSTEMIC SCLEROSIS Inflammatory MYOPATHY ULTRASTRUCTURE
年,卷(期) 2018,(1) 所属期刊栏目
研究方向 页码范围 1-7
页数 7页 分类号 R73
字数 语种
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研究主题发展历程
节点文献
APOPTOSIS
SKELETAL
Muscle
Fiber
SYSTEMIC
SCLEROSIS
Inflammatory
MYOPATHY
ULTRASTRUCTURE
研究起点
研究来源
研究分支
研究去脉
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相关学者/机构
期刊影响力
显微镜研究(英文)
季刊
2329-3306
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
34
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0
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