A Novel Dihydropyridines C-Glycosylated Compound by Hantzsch Cyclo-Condensation

• 作者: Shabnam Madjdpour Soheila Sedaghat
• 来源期刊: 合成理论与应用(英文)
• 学科: 化学
• 关键词: 1 4-Dihydropyridines c-Glycosylated Multi Component REACTION HANTZSCH REACTION
• 年，卷（期）: 2018,（2）
• 页码范围: 17-29
• 页数: 13页
• 分类号: O6

摘要

The Hantzsch synthesis has been used for the preparation of the 1,4-Dihydropyridines compounds with different pharmacophore groups. The use of a designed glycosylated compound in Hantzsch synthesis would lead to a novel Dihydropyridines C-Glycosylated compound. We used the 6-methoxy-2, 2-dimethyltetrahydrofuro [3, 4-d] [1, 3] dioxole-4-carbaldehyde as a glycosylated-based aldehydes. The 4-(3,4-Dihydroxy-5-methoxy-tetrahydro-furan-2-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxy-lic acid 3-ethyl ester 5-methyl ester was synthesized. The structure of compounds was determined by NMR spectroscopy, FTIR and mass spectroscopy methods. We synthesized this 1,4-Dihydropyridines compound by ionic liquid under ultrasound irradiation as a green chemistry synthesis.