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摘要:
Surface layer (S-layer) proteins are one of the most commonly observed cell envelope components in both Archaea and Bacteria. It has versatile functions and holds considerable application potential in biotechnology. Bifidobacteria are representative probiotics conferring health promoting properties. However, there is little study of S-layer in bifidobacteria yet. The distribution and characteristics of S-layer in bifidobacteria are unknown. In this study, search for S-layer protein in the identical protein groups in NCBI yielded 49 hits belonging to bifidobacteria. These proteins were annotated as either “S-layer (domain) protein” or “putative S-layer (y) domain protein” that distributed among 26 species of Bifidobacterium genus. Multiple alignments suggest S-layer proteins are relatively conservative. Phylogenetic analysis of 24 S-layer (domain) protein sequences groups them into three distinct clusters, with the majority species in Cluster-2. S-layer (domain) protein has a universe motif DUF4381, though its function is unknown. Meanwhile, two other motifs CARDB and EphA2_TM involved in cell adhesion and cell signaling respectively, presented in most S-layer (domain) protein in bifidobacteria. All S-layer proteins have a typical N-terminal Sec-dependent signal peptide and a C-terminal trans-membrane region. Homological modeling of representative S-layer proteins from each cluster revealed a few unique structural features. All representative S-layer proteins have a plenty of β-meander motif that exclusively composed by β-barrel structural architectures linked together by hairpin loops.
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篇名 Bioinformatic Survey of S-Layer Proteins in Bifidobacteria
来源期刊 计算分子生物学(英文) 学科 医学
关键词 BIFIDOBACTERIA S-LAYER DOMAIN Protein PHYLOGENY HOMOLOGY Modeling DOMAIN
年,卷(期) 2018,(2) 所属期刊栏目
研究方向 页码范围 68-79
页数 12页 分类号 R73
字数 语种
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研究主题发展历程
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BIFIDOBACTERIA
S-LAYER
DOMAIN
Protein
PHYLOGENY
HOMOLOGY
Modeling
DOMAIN
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研究去脉
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期刊影响力
计算分子生物学(英文)
季刊
2165-3445
武汉市江夏区汤逊湖北路38号光谷总部空间
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35
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0
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