Vitamin D in esophageal cancer:Is there a role for chemoprevention?

• 作者: Carol Rouphael Afrin Kamal Madhusudhan R Sanaka Prashanthi N Thota
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: VITAMIN D VITAMIN D receptor ESOPHAGEAL ADENOCARCINOMA ESOPHAGEAL SQUAMOUS cell carcinoma genetic polymorphism
• 年，卷（期）: 2018,（1）
• 页码范围: 23-30
• 页数: 8页
• 分类号: R

摘要

Vitamin D has emerged as a promising anti-cancer agent due to its diverse biological effects on tumor differentiation,apoptosis and suppression of cellular proliferation.Current evidence suggests a protective role of vitamin D in colon cancer.The effect of vitamin D on esophageal cancer remains controversial.Multiple studies investigated the association between vitamin D and esophageal cancer,employing different modes of assessment of vitamin D status such as serum 25-hydroxyvitamin D levels,vitamin D dietary intake or exposure to ultraviolet B(UVB)radiation.Genetic variations of the vitamin D receptor(VDR)gene and VDR expression in esophageal specimens have also been investigated.Ecological studies evaluating exposure to UVB radiation yielded an inverse correlation with esophageal cancer.When vitamin D dietary intake was assessed,direct association with esophageal cancer was observed.However,circulating 25-hydroxyvitamin D concentrations showed inconsistent results.In this review article,we present a detailed summary of the current data on the effects of vitamin D on various histological subtypes of esophageal cancer and their precursor lesions.Well-powered prospective studies with accurate measurement of vitamin D status are needed before chemoprevention with vitamin D is recommended,as current evidence does not support a chemopreventive role of vitamin D against esophageal cancer.Future studies looking at the incidence of esophageal cancer in patients with pre-cancerous lesions(Barrett's esophagus and squamous cell dysplasia)receiving vitamin D supplementation are needed.