The Application of New Chiral Ferrocene Ligands in Asymmetric Transfer Hydrogenation of Ketones

• 作者: Hui-Fang Nie Qiao-Feng Wang Quan-Jun Wang Yuan-Zhao Mo
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Asymmetric Transfer HYDROGENATION FERROCENE LIGAND KETONE
• 年，卷（期）: yjhxgjqkyw_2018,（1）
• 页码范围: 54-83
• 页数: 30页
• 分类号: O6

摘要

Four easily available ferrocenyl chiral ligands have been screened firstly for ruthenium (II)-catalyzed asymmetric transfer hydrogenation of acetophenone with HCOOH/Et3N azeotrope as the hydrogen source. A moderate chemical yield of 1-phenylethanol with 83% ee was obtained when (RC, SFc)-1-(Diphe-nylphosphino)-2-[1-N-(3-methylpyridin-2-ylmethyl) ethyl] ferrocene (L1) was used. Particularly, both ruthenium and iridium could coordinate with L1 to accomplish the asymmetric reduction of series of aromatic ketones separately. The desired products were achieved with up to 86% ee.<