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AIM To determine the effect of childhood obesity and insulin resistance on bone health.METHODS We conducted a cross sectional study in pubertal adolescents and young adults 13-20 years old who were either overweight/obese or normal weight.Participants were Tanner 3 or above for pubertal stage,and had fasting blood work done to measure glucose,insulin,C-reactive protein and lipid levels.Homeostatic model of insulin resistance(HOMA-IR)was calculated using the formula(Fasting Blood Glucose*Insulin/405).Body composition and bone mineral density were measured using dual energy X-ray absorptiometry(DXA;Hologic QDR 4500,Waltham,MA,United Kingdom).RESULTS Percent trunk fat was associated inversely with whole body bone mineral content(BMC),whereas HOMA-IR was associated positively with whole body BMC.CONCLUSION Our results suggest that abdominal adiposity may have an adverse effect on whole body bone parameters and that this effect is not mediated by insulin resistance.
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篇名 Abdominal obesity adversely affects bone mass in children
来源期刊 世界临床儿科杂志 学科 医学
关键词 OBESITY BONE MINERAL density INSULIN resistance
年,卷(期) 2018,(1) 所属期刊栏目
研究方向 页码范围 43-48
页数 6页 分类号 R
字数 语种
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研究主题发展历程
节点文献
OBESITY
BONE
MINERAL
density
INSULIN
resistance
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研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界临床儿科杂志
不定期
2219-2808
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
134
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0
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0
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