Development and optimization of nanoemulsion gel for topical delivery of imiquimod

• 作者: Deepak N.Kapoor Gurvinder Kaur Tanurajvir Kaur
• 来源期刊: 中国药学（英文版）
• 学科: 医学
• 年，卷（期）: 2018,（1）
• 所属期刊栏目: 研究论文
• 页码范围: 31-39
• 页数: 9页
• 分类号: R944
• 语种: 英文

摘要

In the present study,we aimed to formulate,optimize and characterize nanoemulsion-based gel of imiquimod for its topical administration and to improve the drug permeation.Nanoemulsions were prepared by the aqueous phase titration method and spontaneously formed by mixing specific fractions of oil phase:Smix:water.The nanoemulsion formulations were optimized by response surface methodology (RSM) using mixture design,Scheffe model.The formulated nanoemulsion was incorporated into 0.5％ Carbopol 934 (w/v) to enhance convenience in superficial application of the drug.The nanoemulsions were characterized in terms of droplet size,zeta potential,TEM,DSC and in vitro drug permeation.The vesicle size was 113.6 nm with polydispersity index of 0.251.The zeta potential was 34 mV.The spherical droplet shape was confirmed by TEM analysis.The drug permeation from the diffusion membrane was 73.67％ in 6 h for the optimized formulation.An optimized nanoemulsion gel formulation of imiquimod was successfully developed with improved permeation using experimental design technique.The developed formulation could be further explored as a potential alternate to currently available topical formulations for the treatment of genital warts.