Effect of Chronic Aluminum Administration on Affective and Cognitive Behavior in Male and Female Rats

• 作者: Abdelhalem Mesfioui Aboubaker El Hessni Ali Ouichou Ayoub Rezqaoui Azzouz Essamri El-Housseine Rifi Jihane Chaibat Mouloud Lamtai Oussama Zghari Sihame Ouakki
• 来源期刊: 行为与脑科学期刊(英文)
• 学科: 医学
• 关键词: ALUMINUM ANXIETY DEPRESSION Memory BEHAVIORAL Tests WISTAR Rat
• 年，卷（期）: 2018,（4）
• 页码范围: 179-196
• 页数: 18页
• 分类号: R73

摘要

In this study, we investigated the effect of chronic exposure of low doses of Aluminum on affective and cognitive disorders in male and female rats. Twenty-five rats for each gender are used and the treatment carried out for 8 weeks. Animals received distilled water for control or an intraperitoneal injection of different doses of Aluminum: 0.125, 0.25, 0.5 and 1 mg/kg. Behavioral performance is measured in various tests mainly the Open Field, Elevated Plus Maze, Force Swimming Test, Morris Water Maze, Y-maze and Object Recognition Test. Al exerts anxiogenic properties and depressive effect. The effect begins at 0.25 mg/kg to reach a maximum at 1 mg/kg. In addition, chronic exposure to Aluminum causes cognitive disorders characterized by affection of memory and influence spatial learning performance. The effect of Aluminum on working memory is effective just at 1 mg/kg, while the effect on spatial learning performance begins at 0.25 mg/kg to reach a maximum at 1 mg/kg. In conclusion, Aluminum enhances anxiety and depression parameters and cognitive disorders characterized by the affection of memory and spatial learning performance.