Synthesis and Antifungal Activity of Some New Fluorine-Substituted 4-Thiazolidinone Bearing 1,2,4-Triazinone

• 作者: Layla A. Taib
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: SYNTHESIS FLUORINE 4-THIAZOLIDINONE 1 2 4-Triazin FUNGAL
• 年，卷（期）: 2018,（1）
• 页码范围: 170-175
• 页数: 6页
• 分类号: O6

摘要

Fluorine substituted 4-thiazolidinone 5 bearing 1,2,4-triazinone obtained from the condensation of 3-Amino-6(2’-aminophenyl)-1,2,4-triazin-5(4H)-one (2) with an aromatic aldehyde followed by cycloaddition with mercaptoacetic acid afforded the thiazolidinone (4), and treatment with ethyl trifluoroacetate. Structure of the products has been deduced from their correct elemental analysis and spectral measurements. The antifungal activity of the new fluorinated target also has been evaluated.