Effect of Added Cu(OTf)<sub>2</sub>on the Cu(OTf)<sub>2</sub>(Py)<sub>4</sub>-Mediated Radiofluorination of Benzoyl and Phthaloylglycinates

• 作者: David W. Blevins Dustin R. Osborne George W. Kabalka Murthy R. Akula
• 来源期刊: 自然科学期刊(英文)
• 学科: 化学
• 关键词: Glycinates BORONATE Esters Gorlos-Phos Radiofluorination Copper TRIFLATE
• 年，卷（期）: zrkxqkyw_2018,（3）
• 页码范围: 125-133
• 页数: 9页
• 分类号: O6

摘要

Cu(OTf)2(Py)4 mediated radiofluorination of the boronate esters of ethyl benzoyl and phthaloylglycinates (11 and 16) using 10 mol% of the copper complex following the literature procedure did not provide the fluorinated products. However, the addition of Cu(OTf)2resulted in the radio-fluorination of the boronate esters 11 and 16 to obtain ethyl 4-[18F]fluorobenzoyl glycinate, 17, (48%) and ethyl 3-[18F]phthaloylglycinate (41%) respectively.