Influence of Dosimetric Considerations in Evaluating Second Cancer Risks in Prostate Cancer

• 作者: Ehab M. Attalla Mostafa A. lnaggar Raghda A. Elgendy Wahib M. Attia
• 来源期刊: 医学物理学、临床工程、放射肿瘤学(英文)
• 学科: 医学
• 关键词: PROSTATE CANCER Second CANCER RISKS 3DCRT ROTATIONAL Arc and IMRT
• 年，卷（期）: 2018,（2）
• 页码范围: 203-213
• 页数: 11页
• 分类号: R73

摘要

Influence of dosimetric considerations in evaluating second cancer risks in prostate cancer. Material and methods: Fifteen patients in this study suffering from early stage of prostate cancer, each patient underwent three plans: 1) Three-dimensional conformal radiation therapy (3DCRT), 2) Rotation therapy (Arc therapy), and 3) intensity-modulated radiation therapy (IMRT) plan. Estimate secondary metastasis risk models: Excess Relative Risk (ERR) and Excess absolute risk (EAR) based on age of exposure by taking dosimetry data from Dose Volume Histograms (DVHs) to calculate risk models. Result: The second cancer risk models (ERR and EAR) for organs at risk OARs decrease with increasing age of exposure for 3D-CRT, ARC and IMRT and there is no significant difference for ERR and EAR model for developing second cancer risk in 3D-CRT, ARC and IMRT.