A Concept for a Novel Test for Chemical Parity

• 作者: Heinz Langhals Oswald Krotz
• 来源期刊: 绿色与可持续化学(英文)
• 学科: 化学
• 关键词: CHIRALITY PARITY Circular DICHROISM UV/Vis SPECTROSCOPY RACEMATES
• 年，卷（期）: 2018,（4）
• 页码范围: 311-319
• 页数: 9页
• 分类号: O6

摘要

Deviations from chemical parity (PV) were evaluated with the search for very small enantiomeric excesses in a racemate prepared from non chiral materials and were detected by means of the circular dichroism (CD). Thus, intensely light-absorbing perylenebiscarboximides were attached to axially chiral biphenyls for the amplification of CD effects by exciton interactions of the adjacent chromophores. A rapidly racemising system was applied for the exclusion of artifacts and compared with an analogous with locked chirally. A very slight enantiomeric excess was detected for the (M) enantiomer. Application of the method for other systems was suggested and relations to natural products discussed.