Synthesis of New Fluorinated Amino-Heterocyclic Compounds Bearing 6-Aryl-5-Oxo-1,2,4-Triazin-3-Yl Moiety as Antimicrobial Agents

• 作者: Reda M. Abdel-Rahman Wafa A. Bawazir
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Facile Synthesis Fluoro-Amino-1 2 4-Triazines Antimicrobials
• 年，卷（期）: 2018,（4）
• 页码范围: 349-358
• 页数: 10页
• 分类号: O6

摘要

Some more new fluorine substitutedamino compounds bearing 6-aryl-5-oxo-1,2,4-triazin-3-yl moieties and its derivatives 3 - 7 have been synthesised successfully from aroylation of 6-(2’-aminophenyl)-3-thioxo-1,2,4-triazin-5-one (1), followed by fluoro amination with 4-fluoroanilinein Abs EtOH and then treated with ammonia/EtOH and finally acylation/aroylation or cyclocondensation reactions with malonic acid in AcOH. Structure of the products has been established upon elemental analysis and their spectral measurements. All the obtained compounds evaluated as antimicrobial agents were the compounds which contained both nitro and fluorine elements and exhibited a highly activity the other derivatives.