Evaluation of Antimycotic Activity of Extracts of Marine Algae Collected from Red Sea Coast, Jeddah, Saudi Arabia

• 作者: Amal El-Naggar Danyah Al-Sobahi Huda Sheikh
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: Marine ALGAE Seaweeds ANTIFUNGAL ACTIVITY Solvent EXTRACTS Minimal Inhibitory Concentrations (MICs)
• 年，卷（期）: 2018,（4）
• 页码范围: 51-68
• 页数: 18页
• 分类号: R28

摘要

In the present study, fifteen species of the dominant marine algae were collected during summer 2013 from four selected sites on Red sea coast, Jeddah, Saudi Arabia. The collected species belonged to Chlorophyta, Phaeophyta and Rhodophyta. Crude algal extracts were prepared by successive extractions using different solvents (acetone, ethanol, diethyl ether, ethyl acetate, methanol and petroleum ether). The crude algal extracts were examined for their antifungal efficacy against Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Candida albicans and Candida tropicalis using agar well diffusion method. The algal extracts evoked different patterns of antifungal activities. Results reveal that acetone was the best solvent suited for extraction of bioactive compounds from tested seaweeds with inhibition activity (19.3%) followed by ethyl acetate (17.1%), ethanol (16.4%), petroleum ether (15.9%), diethyl ether (15.85%), and finally methanol (15.4%). Chlorophyta exhibited the highest antimycotic effect followed by Rhodophyta and Phaeophyta. In Chlorophyta, the extracts of Ulva intestinalis were the most potent followed by U. lactuca, C. racemosa, U. linza and U. reticulate. Acanthophora spicifera showed the highest activity in Rhodophyta, followed by J. rubens, D. simplex, L. obtusa, G. gracilis, G. vermicuphylla and G. multipartita. Whereas, T. triquetra was the most effective species in Phaeophyta followed by P. pavonica and D. dichotoma. The minimal inhibitory concentrations (MICs) of the most potent algal extracts were in the range of 0.5 to 4 mg/ml. The results confirmed the antimycotic potentiality of seaweed extracts.