The Relationship between Serum Pentraxin-3 Levels and Severity of Coronary Heart Disease

• 作者: Mai Abdel Ra’ouf Mohamed Yahia Omar S. Elmasry
• 来源期刊: 心血管病(英文)
• 学科: 医学
• 关键词: CORONARY ARTERY Disease Pentraxin-3 SYNTAX SCORE
• 年，卷（期）: 2018,（7）
• 页码范围: 370-380
• 页数: 11页
• 分类号: R5

摘要

Background: Clinical data suggested that pentraxin-3 is a biomarker for atherosclerosis due to its role in inflammatory processes since it exerts unfavorable effects on the course of atherosclerosis, stimulates plaque formation, and augments vascular inflammation. Objective: The aims of this study were to measure the level of serum pentraxin-3 in patients with suspected coronary artery disease (CAD) and to determine whether it was associated with the severity of CAD. Material and Methods: The serum pentraxin-3 level was measured by enzyme-linked immunosorbent assay in 80 patients who were referred for elective coronary angiography due to positive stress test results. SYNTAX score was used to determine the severity of CAD. Results: The study cohort consisted of 45 (56.25%) males and 35 (43.75%) females with a mean age of 55 ± 9.8 years. The mean serum pentraxin-3 level was 3.79 ± 1.38 ng/ml, and the mean SYNTAX score was 15.8 ± 11.3. A significant correlation was observed between pentraxin-3 level and SYNTAX score (r = 0.459, p - 32 or ≤22 (p = 0.002). Conclusion: The serum level of inflammatory marker pentraxin-3 is increased in patients with CAD and is correlated with the severity of CAD.