Hormone Replacement Therapy for Restoring the HPG Axis in Pain Patients Treated with Long-Term Opioid Analgesics

• 作者: Jo Ann Le Quang Joseph V. Pergolizzi III Joseph V. Pergolizzi Jr. Robert B. Raffa Robert Taylor Jr. Srinivas Nalamachu
• 来源期刊: 药理与制药(英文)
• 学科: 医学
• 关键词: OPIOID THERAPY Chronic PAIN HPG AXIS HORMONE REPLACEMENT THERAPY
• 年，卷（期）: 2018,（11）
• 页码范围: 473-480
• 页数: 8页
• 分类号: R73

摘要

Opioids are a treatment option for a variety of chronic pain conditions. But long-term opioid use can be associated with side effects, including hypogonadism. Opioid-induced hypogonadism (OIhG) is associated with the alteration of the hypothalamic-pituitary-gonadal axis (HPG). In males, hypogonadism can result in erectile dysfunction, reduced libido, fatigue, worsening mood, and increased risk of osteoporosis;in females, it can result in changes in the menstrual cycle and reduced libido, among other effects. A current treatment option for these patients is hormone replacement therapy. In this report, we discuss the problem of opioid-induced hypogonadism, and the therapeutic approach and the potential complications of treating pain patients using hormone replacement therapy.