Antidepressant-Like Activity of Methanolic Extract of the Seeds of <i>Trachysperum ammi</i>in Swiss Albino Mice

• 作者: Md. Abdul Mannan Md. Rashidur Rahman Md. Shahed-Al-Mahmud Mohammad Ali Mostakim Sharif Sadiur Rahman Sajon
• 来源期刊: 药理与制药(英文)
• 学科: 医学
• 关键词: Trachysperum AMMI ANTIDEPRESSANT CNS STIMULANTS Forced Swimming
• 年，卷（期）: 2018,（12）
• 页码范围: 503-514
• 页数: 12页
• 分类号: R73

摘要

Trachysperum ammi has been traditionally used for the treatment of neurological disorders such as depression and anxiety. To date, T. ammi has reported for its chemical constituents in different diseases condition. The traditional evidence convinced us to perform the antidepressant-like activity of methanolic extract of Trachysperum ammi (META). The antidepressant activity of META assessed by using forced swimming test (FST), tail suspension test (TST), and locomotor activity test. The seed parts of META at doses level of 50, 100 and 200 mg/kg body weight administered orally to examine the CNS stimulants activity test in mice behavioral models. Here, we reported that META significantly reduced immobility time in the FST after repeated administration of 50, 100 and 200 mg/kg to mice for 14 days. The intensity of immobility significantly reduced at all of the doses (p < 0.05) whereas, we were found the strongest effect observed at 200 mg/kg. The antidepressant-like effect of META caused the reduction (p < 0.05) in the immobility in TST of mice when orally administered with 50, 100 and 200 mg/kg for 14 days, respectively. Additionally, we were executed locomotor activity test to check the motor stimulating activity. META has employed at a dosage of 50, 100 and 200 mg/kg for 14 days, the results have found that 50 mg/kg produced the locomotion effects as similar to the control group. Interestingly, the locomotion, rearing, and defecation significantly (p < 0.05) increased at the dosage of 100 and 200 mg/kg of META. Our present findings suggest that the seed parts of Trachysperum ammi may possess antidepressant-like activity which may use as a supportive treatment to management of neurological disorders.