There is some evidence consistently linking the occurrence of de novo obsessive-compulsive disorder(OCD)with clozapine.This skin-picking disorder is also known as impulsive-compulsive disorder-unspecified which with an increasing convergence with OCD has been placed in the current Diagnostic and statistical manual of mental disorders-fifth edition by American Psychiatric Association(DSM-5),in the category of the obsessive-compulsive and related disorders.To the best of our knowledge,there is no literature relating antipsychotics like clozapine with the occurrence of skin-picking behaviour.In this article,we present a case in whom skin-picking behaviour emerged during the upward dose titration of clozapine and was successfully treated with escitalopram.