[1] In Robert Burton's mammoth 1621 The Anatomy of Melancholy,a meandering discourse on soul-sickness,Burton treats melancholy as a universal phenomenon,endemic to the human condition:"Kingdoms and provinces are melancholy,cities and families,all creatures,vegetable,sensible,and rational-that all sorts,sects,ages,conditions,are out of tune...For indeed who is not a fool,melancholy,mad?"