Free Radical Activity as Diagnostic and Prognostic Criteria in Solid Tumors and Their Therapy

• 作者: E. I. Erlykina L. M. Obukhova T. V. Kopytova
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: Free RADICAL ACTIVITY OXIDATIVE Modification Blood Plasma PROTEINS Cancer CHEMOTHERAPY Efficiency
• 年，卷（期）: 2018,（12）
• 页码范围: 1-12
• 页数: 12页
• 分类号: R73

摘要

Blood plasma of 39 cancer patients who had not previously undergone anti-tumor treatment, and 21 patients with recurrent epithelial tissues cancer before treatment and after the first course of chemotherapy were investigated. The treatment effectiveness of patients with relapse was evaluated throughout the year. The control group was the blood plasma of 14 healthy people. Free radical activity and oxidative modification of proteins were assessed in blood plasma. In malignant neoplasms of epithelial tissues, free radical activity and oxidative modification of plasma proteins are significantly higher. At the initial stages of carcinogenesis, the oxidative modification level of plasma proteins increases both due to aldehyde and ketone carbonyl derivatives. In the terminal stage of malignant tumors, an increase in the oxidative modification of proteins occurs due to aliphatic ketone dinitrophenyl hydrazones, which are the markers of protein aggregation characteristic of the late stages of oxidative stress. In case of an objective response to polychemotherapy, there is a significant decrease in free radical plasma activity after the first course of therapy and a significant increase in carbonyl derivatives recorded at a wavelength of 230 nm, which can serve as a marker of its effectiveness.