Gadolinium Oxide Nanocrystals Sensitize Non-small Cell Lung Cancer Cells to X-ray Irradiation via Promoting Cytostatic Autophagy

• 作者: Chen Weiqiang Jin Xiaodong Li Feifei Li Qiang Liu Yan
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报:英文版
• 学科: 医学
• 关键词: LUNG NSCLC LUNG
• 年，卷（期）: 2018,（1）
• 页码范围: 143-143
• 页数: 1页
• 分类号: R73

摘要

Gadolinium-based nanoparticles(GdNPs)have been used as theranostic sensitizers in clinical radiotherapy study[1],but the biomechanisms underlying the radiosensitizing effect of GdNPs are still undisclosed.In this study,ultra-small gadolinium oxide nanocrystals(GON)was employed to investigate their radiosensitizing effect and biological mechanisms in non-small cell lung cancer(NSCLC)cells under X-ray irradiation.Using a polyol method,GON was synthesized[2].In the previous study,GON caused hydroxyl radical production and oxidative stress in a dose-and concentration-dependent manner in NSCLC cells after X-ray irradiation.The radiation enhancements of GON reached 19.3%26.3%for the NSCLC cells under investigation at 10%survival level compared with irradiation alone.