Carbon Induced Lung Cancer Cell Apoptosis with Antennapedia Proteins (ANTP)-SmacN7

• 作者: Xie Yi Zhang Hong
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报:英文版
• 学科: 医学
• 关键词: SMAC DRUGS Apoptosis
• 年，卷（期）: 2018,（1）
• 页码范围: 158-159
• 页数: 2页
• 分类号: R73

摘要

The objective of this study was to investigate the underlying mechanisms behind the antennapedia proteins(ANTP)-SmacN7 synergistically trigger cell apoptosis in lung cancer cells induced by carbon ion irradiation.The radiation-sensitising effects of cancer cells and ANTPSmacN7 fusion proteins were observed by a clonogenic assay[1].The effects of drugs and radiation on tumour cell apoptosis were determined using PI staining[2].Carbon ion radiation-induced tumour cells apoptosis were showed significantly increase compared with X-ray irradiation(IR).The ANTP-SmacN7 fusion protein promoted tumour cell apoptosis.The results indicate that iron and carbon ion IR have higher RBE for cell killing,and ANTP-SmacN7 could significantly promote apoptosis of lung cancer cells induced by high-LET IR.These results provide useful information for followup studies that will focus on improvement of high-LET ion radiotherapy in the near future(Figs.12).