CX3CR1 receptor as a potential therapeutic target in chronic rhinosinusitis and allergic rhinitis

• 作者: Amr El-Shazly
• 来源期刊: 世界耳鼻咽喉科杂志
• 学科: 医学
• 关键词: Nasal Inflammation CX3CR1 RECEPTOR Chronic RHINOSINUSITIS Allergic RHINITIS Therapeutic MODALITIES
• 年，卷（期）: 2019,（1）
• 页码范围: 1-2
• 页数: 2页
• 分类号: R

摘要

Chronic rhinosinusitis and allergic rhinitis are chronic inflammatory diseases that affect the mucous membrane of the nose and paranasal sinuses. These diseases are characterized by recruitment of inflammatory cells to the upper airway. For this to take place a complex interaction between inflammatory cells and the cytokines/chemokines (ligand) liberated at the site of inflammation is involved in a process termed chemotaxis or directed cell migration against concentration gradient of the ligand. This entails signal transduction through the cell surface receptor resulting in cellular functional response and directed migration. In this editorial the novel role of CX3CR1 receptor in the immunopathology of chronic inflammation of the nose and paranasal sinuses will be explored with its potential role as therapeutic target in chronic nasal inflammation.