An Associated Research for Genetic Polymorphism of 5-HTTLPR with Post-Traumatic Stress Disorder

• 作者: Jianhong Pan Juncheng Guo Min Guo Ping Huang Xiangling Jiang Yijun Yang Zhuo Liu
• 来源期刊: 行为与脑科学期刊(英文)
• 学科: 医学
• 关键词: POSTTRAUMATIC Stress DISORDER Gene POLYMORPHISM 5-HTTLPR GENETICS
• 年，卷（期）: 2019,（1）
• 页码范围: 1-12
• 页数: 12页
• 分类号: R73

摘要

The aim of this study was to investigate the influence of a polymorphism in the serotonin transporter gene (5-HTTLPR) in patients diagnosed with posttraumatic stress disorder (PTSD) in a Chinese sample of earthquake survivors. Polymerase chain reaction (PCR) amplification and amplified fragment length polymorphism (AFLP) were performed to type 5-HTTLPR promoter polymorphism in 57 PTSD patients and an equal number of healthy controls. The genotype and allele frequency distribution were analyzed and compared using various statistical methods. The frequency of LL, SL and SS genotypes in patients was found to be 5, 16 and 36 respectively, in comparison to 16, 22 and 19 in healthy controls. Fewer patients tended to be L genotype (22.8%) than controls (47.4%), but the number of patients with the S genotype was higher (77.2%) compared to controls (52.6%). The results show a statistically significant difference in genotype and allele frequency distribution between patients and controls. This research suggests that PTSD symptoms are significantly associated with 5-HTTLPR genetic polymorphism. These results add to the important research of genetics of psychiatric disorders, particularly in a Chinese context that has not been previously studied.