The <i>in Vivo</i>Antioxidant Effects of (−)-Epigallocatechin-3-Gallate Consumption in Healthy Postmenopausal Women Measured by Urinary Excretion of Secondary Lipid Peroxidation Products

• 作者: A. Saari Csallany Chelsey Fiecke Chi Chen Mindy Kurzer
• 来源期刊: 食品与营养科学(英文)
• 学科: 医学
• 关键词: Antioxidants Epigallocatechin-3-Gallate Green Tea Humans Lipid PEROXIDATION Urinary EXCRETION
• 年，卷（期）: 2019,（1）
• 页码范围: 15-27
• 页数: 13页
• 分类号: R73

摘要

The present study was carried out to determine whether the consumption of epigallocatechin (EGCG), the major bioactive green tea catechin, exerts a positive effect on lowering in vivo lipid peroxidation, a measure of oxidative stress, in healthy postmenopausal women. Urinary excretion of secondary lipid peroxidation products, a measure of in vivo lipid peroxidation, was determined in 40 participants randomly assigned to consume a green tea catechin extract (843.0 ± 44.0 mg EGCG/d) or placebo capsules for 12 months. Urine samples were analyzed for individual polar and nonpolar lipophilic aldehydes and related carbonyl compounds by high-performance liquid chromatography (HPLC) at the beginning and at the end of the 12-month intervention period. Results show that two nonpolar aldehydes, nonanal and decatrienal, were both 48% lower (p in vivo antioxidant activity exists with long-term EGCG consumption, which could slightly limit oxidative damage associated with lipid peroxidation and the onset and progression of chronic diseases.