Towards a multiphysics modelling framework for thermosensitive liposomal drug delivery to solid tumour combined with focused ultrasound hyperthermia

• 作者: Wenbo Zhan Wladyslaw Gedroyc Xiao Yun Xu
• 来源期刊: 生物物理学报:英文版
• 学科: 生物学
• 关键词: CHEMOTHERAPY Drug delivery High intensity FOCUSED ultrasound Mathematical model THERMOSENSITIVE LIPOSOME
• 年，卷（期）: 2019,（1）
• 页码范围: 43-59
• 页数: 17页
• 分类号: Q

摘要

Systemic toxicity and insufficient drug accumulation at the tumour s让e are main barriers in chemotherapy. Thermosens让ive liposomes (TSL) combined with high intensity focused ultrasound (HIFU) has emerged as a potential solution to overcome these barriers through targeted drug delivery and localised release. Owing to the multiple physical and biochemical processes involved in this combination therapy, mathematical modelling becomes an indispensable tool for detailed analysis of the transport processes and prediction of tumour drug uptake. To this end, a multiphysics model has been developed to simulate the transport of chemotherapy drugs delivered through a combined HIFU-TSL system. All key delivery processes are considered in the model;these in elude interstitial fluid flow, HIFU acoustics, bioheat transfer;drug release and transport, as well as tumour drug uptake. The capability of the model is demonstrated through its application to a 2-D prostate tumour model reconstructed from magnetic res on ance images. Our results not only dem on strate the feasibility of the model to simulate this combination therapy, but also confirm the advantage of HIFU-TSL drug delivery system with enhancement of drug accumulati on in tumour regi ons and reduction ofdrug availability in n ormal tissue. This multiphysics modelling framework can serve as a useful tool to assist in the design of HIFU-TSL drug delivery systems and treatment regimen for improved anticancer efficacy.