Effects of Elasticity on Wall Shear Stress in Patient-Specific Aneurysm of Cerebral Artery

• 作者: Ahmad Zahran Md Khudzari Atsushi Saito Gaku Tanaka Hitomi Anzai Kahar Osman Kazuhiro Watanabe Makoto Ohta Nadia Shaira Shafii Ryuhei Yamaguchi Simon Tupin Taihei Kotani
• 来源期刊: 流量控制、测量及可视化(英文)
• 学科: 医学
• 关键词: CEREBRAL ANEURYSM ELASTICITY Particle Image VELOCIMETRY Wall SHEAR Stress
• 年，卷（期）: 2019,（2）
• 页码范围: 73-86
• 页数: 14页
• 分类号: R73

摘要

The behavior of wall shear stress (WSS) was previously reported in a deformable aneurysm model using fluid-structure interactions. However, these findings have not been validated. In the present study, we examined the effect of elasticity (i.e., deformation) on wall shear stress inside a cerebral aneurysm at the apex of a bifurcation using particle image velocimetry in vitro. The flow model simulated a human patient-specific aneurysm at the apex of the bifurcation of the middle cerebral artery. Flow characteristics by wall elasticity were examined for both elastic and non-deformable aneurysm models with pulsatile blood flow. The absolute temporally- and spatially-averaged WSS along the bleb wall was smaller in the elastic model than that in the non-deformable model. This small WSS may be related to attenuation of the WSS. Further, the WSS gradient had a finite value near the stagnation point of the aneurysm dome. Finally, the WSS gradient near the stagnation point was slightly smaller in the elastic model than that in the non-deformable model. These data suggest that elasticity of the aneurysm wall can affect the progression and rupture of aneurysms via hemodynamic stress.