Analysis of herbs use law and mechanism of traditional Chinese medicine in preventing and treating postoperative complications of breast cancer

• 作者: Guo-Wei Zhang Li-Hui Zhang Mei-Ting Liu Miao-Miao Lin Yao Yang
• 来源期刊: TMR药物联合治疗
• 学科: 医学
• 关键词: POSTOPERATIVE breast cancer Complications Data mining Path ANALYSIS MEDICATION LAW MECHANISM of action
• 年，卷（期）: 2019,（2）
• 页码范围: 40-55
• 页数: 16页
• 分类号: R

摘要

Objective:Excavate the compatibility rules of traditional Chinese medicine for preventing and treating postoperative complications of breast cancer,study the potential mechanism of prevention and treatment with traditional Chinese medicine.Methods:Collate and analyze the relevant prescriptions collected from CNKI and the core drug combination and the new formula are obtained by adopting the traditional Chinese medicine inheritance auxiliary system(TCMISSV2.5).Use BATMAN-TCM online analysis tool to analyze KEGG pathways of high frequency drugs and predict the potential signal pathways.Results:Data mining has selected 10 pairs of core herb combinations and 5 new recipes of 133 prescriptions.In the network pharmacology analysis of bai zhu,huang qi,fu ling,the potential signaling pathways of its action are the neuroactive ligand-receptor interaction pathway and calcium signaling pathway.Conclusion:Herbs for invigorating spleen and qi and herbs for nourishing blood and activating blood are commonly used to prevent and treat postoperative complications of breast cancer.Core herbs may play their role by interfering with the neuroactive ligand-receptor interaction pathway and calcium signaling pathway.