Effectiveness and Tolerance of Tenofovir Disoproxil Fumarate in Sub-Saharan Viral B Cirrhotic Patients

• 作者: A. Konaté A. Kondé A. M. Diallo D. Sangare Doumbia K. Wife Samaké M. C. Tounkara M. T. Diarra M. Y. Dicko M. Y. Ma?ga Sanogo S. D. Wife Sidibe Sow H. Wife Coulibaly
• 来源期刊: 肠胃病学期刊(英文)
• 学科: 医学
• 关键词: CIRRHOSIS TENOFOVIR HBV
• 年，卷（期）: 2019,（2）
• 页码范围: 43-47
• 页数: 5页
• 分类号: R73

摘要

Tenofovir reduces viral load during viral cirrhosis B and improves prognosis. The aim of this study was to evaluate the effectiveness and safety of Tenofovir during the treatment of viral B cirrhosis. The study was retrospective and prospective on patients with viral B cirrhosis treated with Tenofovir in the Hepato-Gastroenterology Department of University Hospital Gabriel Touré in Bamako (Mali) and evaluated between three and six months after the start of treatment. We included 89 patients. The mean age was 44.5 ± 16 years with extremes of 18 and 90 years. The sex ratio was 1.2. At inclusion all patients had a detectable viral load with an average of 2651.96 ± 1495.85 IU/ml. Follow-up viral load was undetectable in 84.3% with patients between 3 and 6 months of treatment. The average detectable viral load was only 27.04 ± 21.05 IU/ml. There was also an improvement in hepatocellular function and few side effects. Conclusion: This study shows the interest of Tenofovir in the treatment of viral cirrhosis B with very few adverse effects.