PARK16 rs708730 Polymorphism Decreases Parkinson’s Disease Risk in European Ancestry Population:A Meta-analysis

• 作者: Baochu Wei Chenghong Zhang Dian He Hongtian Zhu Junquan He Lei Tang Pingrong Yang Pingshun Song Ruili Lin Yang Zhang Zhijie Han
• 来源期刊: 老年医学(英文)
• 学科: 医学
• 关键词: Parkinson’s disease Genome-wide association studies META-ANALYSIS PARK16 rs708730 polymorphism
• 年，卷（期）: 2019,（2）
• 页码范围: 15-22
• 页数: 8页
• 分类号: R74

摘要

Parkinson’s disease(PD)is a complex fatal chronic neurodegenerative disease most common in elderly people.The early genome-wide association studies(GWAS)found that the minor allele variant of PARK16 rs708730 polymorphism is a significant protective factor for PD in Caucasian populations.However,these results cannot be repeated by the following studies in Caucasian populations and other populations.We considered that the inconsistency of the findings may be caused by the small-scale samples or the heterogeneity among different populations.Therefore,in this study,we synthesized the previous related GWAS studies through three authoritative sources,and used the large-scale samples(10,645 PD cases and 30,499 controls)to reevaluate the association between rs708730 polymorphism and PD.The results showed that there is no association between them in Asian ancestry population.While,in European ancestry population,we found that the minor allele variant(G)of rs708730 polymorphism is significantly associated with a decreased risk of PD.Collectively,our findings further verified the association of rs708730 with PD and show its genetic heterogeneity among different populations,which can help to develop a better understanding of the PD’s pathogenesis.