Progress toward the Synthesis of Pochonin J

• 作者: Rongson Pongdee Sydney N. Jackson
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: NATURAL Products Pochonin J Resorcylic ACID LACTONES
• 年，卷（期）: yjhxgjqkyw,（2）
• 页码范围: 96-105
• 页数: 10页
• 分类号: O6

摘要

The construction of the C(1) - C(5) fragment of the resorcylic acid lactone pochonin J is described. The synthesis is marked by the installation of the cis-1,3-diol moiety in a highly stereoselective manner using Evans’ intra-molecular base-catalyzed oxyconjugate addition of a hemiacetal-derived nucleophile. The synthetic route presented affords an efficient pathway to the preparation of this critical architectural feature that should facilitate the development of this secondary metabolite as a potential drug candidate.