The lack of adequate and modern transport infrastructures makes the cost of transport in Africa higher than the rest of the world. Most of the transport infrastructures that exist were constructed during the colonial era which makes inter-regional connectivity difficult. The African Union in collaboration with other organization has committed to bridge the transport gap in Africa but still, face some challenges. This paper discusses the main issues that contribute for the weak nature of transportation in Sub-Saharan Africa with regards to the main transport modes and seeks to establish the possibility of sustainable intermodal transport through the integration of the different transport modes. Some policy reforms and other bilateral agreements such as deregulating the transport markets in West and Central Africa have been suggested to facilitate the development of an effective and efficient transport network in the Sub-Saharan African region.