<i>Schistosoma mansoni</i>Infection in <i>Holochilus sciureus</i>Shows Sex-Related Differences in Parasitological Patterns

• 作者: Gleycka Cristine Carvalho Gomes Guilherme Silva Miranda Jo?o Gustavo Mendes Rodrigues Maria Gabriela Sampaio Lira Nêuton Silva-Souza Ranielly Araújo Nogueira
• 来源期刊: 动物科学期刊(英文)
• 学科: 医学
• 关键词: Biological Model Females Males SCHISTOSOMIASIS WILD RESERVOIR
• 年，卷（期）: 2019,（2）
• 页码范围: 173-182
• 页数: 10页
• 分类号: R73

摘要

Due to the different parasitological patterns found between sexes in human populations and in different biological models during Schistosoma mansoni infection, we proposed to investigate such differences using Holochilus sciureus rodent, besides confirming whether this rodent is suitable for experimental infections. In this sense, males and females of H. sciureus were infected with 200 cercariae from a human strain of S. mansoni. The number of eggs per gram of feces (epg) and the worms were quantified, besides histopathological analysis. Thus, it was shown that females have fewer epg, as well as a longer prepatent period. On the other hand, males had a lower recovery rate of adult worms. The histopathological analysis did not show differences between the sexes. Thus, we suggest that infection in H. sciureus females provides a favorable environment for the development of adult worms, despite impairing the parasite fecundity. In addition, H. sciureus may be an excellent biological model for S. mansoni experimental infections.