Mechanism and reversal strategies of immune checkpoint blockers drug resistance

• 作者: Xiao-Hui Liu
• 来源期刊: 精准医学研究
• 学科: 医学
• 关键词: Tumor immunotherapy PD-1/PD-L1 IMMUNE CHECKPOINT BLOCKERS Drug resistance Combined therapy
• 年，卷（期）: 2019,（4）
• 页码范围: 121-124
• 页数: 4页
• 分类号: R73

摘要

Recent years,the immune checkpoint blockers(ICBs)become more and more important in tumor therapy with the development of tumor immunology and achieved significant clinical effects in various solid tumors.ICBs is a type of tumor immunotherapy method which controls and clears tumor by activating the autoimmune system and restoring the body's normal anti-tumor immune response.However,the resistance of ICBs cannot be ignored and still faces many challenges.The mechanism and the solution of ICBs resistance need to be further research.